commercialization in Toronto

Stem Cell Therapeutics Merger, Technology Featured in Biotechnology Focus

Dr. Aaron Schimmer, University Health Network — **Dr. Aaron Schimmer** of the University Health Network discovered that Tigecycline was effective in killing leukemia cells and leukemia stem cells by shutting down their energy supply.

In a November 25 article in Biotechnology Focus magazine, author Shawn Lawrence highlights Stem Cell Therapeutics and Trillium Therapeutics Inc. coming together in a reverse merger that creates more opportunities to advance early-stage research.

The article profiles Dr. Aaron Schimmer and his discovery that Tigecycline is effective in killing leukemia cells and leukemia stem cells by shutting down their energy supply.

Here’s a quote from Lawrence’s article:

“Dr. Schimmer’s research is focused on drug repurposing – finding new indications for approved therapeutics. Focusing on established drugs with known safety profiles can significantly lower the risk in the drug development process, saving time and cost,” says Dr. Niclas Stiernholm, president and CEO of Stem Cell Therapeutics Corp.”

MaRS Innovation focus of Yonge Street Media article on growing technology sectors

November 1, 2013
Susanne Staer
BresoTec Inc.

President and CEO Dr. Raphael Hofstein speaks on healthcare innovation in Toronto

Screen Shot 2013-12-18 at 12.21.01 PM — **Dr. Raphael Hofstein**, MaRS Innovation president and CEO, was featured in an article by *Yonge Street Media*. (Photo Credit: Yonge Street Media)

In an October 30 article, Yonge Street Media‘s Andrew Seale spoke with MI’s president and CEO Raphael Hofstein on the booming healthcare innovation coming from Toronto since 2005.

Seale’s article is the first of a two-part series on technological innovation.

In the article, Hofstein credits the city’s intellectual infrastructure and access to healthcare resources for allowing innovation to flourish.

Three of MI’s start-up companies are also mentioned in the article.

Here’s an excerpt (links and emphasis our own):

“The Intellectual Property that is being generated in Toronto (is) a major chunk of the IP that’s being generated across Canada,” he says.

He points to ChipCare Corporation‘s state-of-the-art handheld analyzer, which allows doctors to run multiple diagnostics on a patient’s blood on site as opposed to bringing the patient to the clinic. The University of Toronto developed cell analyzer could prove to be a game changer in the fight against HIV. “Lab-in-a-chip” technology like this is crucial in third world countries where healthcare access is severely limited.

Xagenic’s AuRA platform—another diagnostic tool for blood samples—uses ultra sensitive microelectrode arrays (nano-sensors) developed by another team of researchers at University of Toronto. The inexpensive tech makes it possible for molecular diagnostic testing outside of labs.

MaRS Innovation-backed ApneaDX has developed a clinical-quality sleep-monitoring tool. Previously, diagnosing for sleep apnea—a sleep disorder characterized by abnormal breathing patterns—often required an expensive overnight stay at a sleep clinic. The device is a fraction of the cost and records the data on a chip, which is then analyzed by the company’s software.

WaveCheck to Transform Chemotherapy Monitoring for Women with Breast Cancer

Indiegogo campaign to raise funds for North American clinical study during Breast Cancer Awareness Month; 12 artists donate 13 original works worth over $15,000 to support campaign

Toronto, Canada (October 9, 2013) — WaveCheck — a painless, non-surgical clinical technique developed by a Sunnybrook Health Sciences Centre oncologist and a Ryerson University physicist and supported by MaRS Innovation — is poised to transform chemotherapy response monitoring for women with breast cancer.

Dr. Gregory Czarnota of Sunnybrook Health Sciences (left) and Professor Michael Kolios of Ryerson University, WaveCheck's inventors. — Dr. Gregory Czarnota of Sunnybrook Health Sciences (left) and Professor Michael Kolios of Ryerson University, WaveCheck’s inventors.

WaveCheck combines traditional ultrasound with new software to detect responses to chemotherapy in breast cancer tissues. By making better, more accurate information available about a woman’s response to her chemotherapy treatment in weeks rather than months, WaveCheck creates greater transparency through dialogue between a women and her doctors, empowering her to participate in discussions about whether a given chemotherapy treatment is effective.

Contribute to WaveCheck‘s Indiegogo campaign and help make this technology available to all women with breast cancer faster.

Media coverage: CTV News Channel, the Globe and Mail and Canadian Healthcare Technology have covered WaveCheck’s campaign.

Developed by Dr. Gregory Czarnota, chief of Radiation Oncology at Sunnybrook’s Odette Cancer Centre, and Michael C. Kolios, professor of Physics and Canada Research Chair in Biomedical Applications of Ultrasound at Ryerson, WaveCheck has been used in clinical studies with nearly 100 women receiving upfront, neoadjuvant chemotherapy to treat locally-advanced breast cancer. These results are published in two leading journals, Clinical Cancer Research and Translational Oncology.

In the Indiegogo campaign video, Czarnota, Kolios and three of the 100 women who participated in the first Sunnybrook study explain WaveCheck’s impact.

“The hard truth for women with breast cancer is that 60 to 70 per cent of chemotherapy treatments fail,” said Czarnota, who is also a senior scientist and director of cancer research at Sunnybrook Research Institute and assistant professor in the University of Toronto’s Departments of Radiation Oncology and Medical Biophysics within the Faculty of Medicine. “The 1.5 million women worldwide who will be diagnosed with breast cancer this year need to know that their chemotherapy is working as soon as possible. But this kind of treatment monitoring doesn’t currently exist in standard clinical practice. Instead, a woman’s tumour response is evaluated after she completes her chemotherapy treatment, which is typically a four- to six-month process.

Cellax profiled in SciBX; MaRS Innovation’s MSc PoP program cited in National Post supplement

The Cellax technology was profiled in a recent issue of SciBX (subscription necessary). MaRS Innovation is mentioned in the article as the technology’s commercialization agent.

Here’s an excerpt:

“Ontario Institute for Cancer Research scientists have developed glycopolymer-conjugated docetaxel nanoparticles that outperform Abraxane in mouse models of breast cancer. The Ontario Institute for Cancer Research (OICR) is backing the program with $1.5 million to take it to the clinic. The expectation is that the product’s ability to target the tumor stroma rather than the tumor itself will differentiate it from Abraxane and other chemotherapeutic formulations.”

Dr. Raphael Hofstein’s MRI blog post: How Team Ontario’s biotechnology takes on the world

Dr. Raphael Hofstein, president & CEO, MaRS Innovation.

Dr. Raphael (Rafi) Hofstein is president and CEO of MaRS Innovation (MI) – the commercialization agent for an exceptional research discovery pipeline stemming from 16 leading Ontario academic institutions. As a single entry point to annual member research and development activity of $1B, MI provides a gateway for investors and licensees who wish to access Ontario’s technology assets.

During the 2012 BIO convention in Boston, Dr. Hofstein blogged about how CQDM of Montreal and MaRS Innovation of Toronto had teamed up to help “fill” the QC-Ontario corridor and why the corridor is good for business in both provinces.

In my previous blog post during BIO2012, I talked about how MaRS Innovation and CQDM had jointly collaborated to form Encycle Therapeutics, a startup that was created around disruptive technology, developed by Professor Andrei Yudin of the University of Toronto, involving the cyclization of biologically active peptides.

A year later, I’m pleased to report that Encycle is alive and kicking. The company has since recruited seasoned management, and its developing product line is drawing tremendous interest from global pharmaceutical groups. In the next few months, we expect Encycle to raise significant capital and establish meaningful ties with strategic allies.

Taking a wider look at the life sciences sector, this has been a vintage year for Ontario in general and MaRS Innovation’s ecosystem in particular.

UTEST named one of Canada’s seven true start-up accelerators

June 10, 2013
Susanne Staer
Awards

The University of Toronto Early-Stage Technology (UTEST) program, part of U of T’s growing ecosystem of incubators and commercialization support services, has been named one of Canada’s seven true start-up accelerators.

The findings come from Helen Kula‘s MaRS Data Catalyst report and were covered by Rob Lewis of TechVibes.

MaRS Discovery District launches MaRS EXCITE to help breakthrough technologies reach patients faster

MI start-up ApneaDx Inc. among program’s first round of participants

The first three companies selected to participate in the MaRS EXCITE program aim to improve outcomes for breast cancer, sleep apnea and drug-resistant hypertension.

The Excellence in Clinical Innovation and Technology Evaluation (EXCITE) initiative helps companies accelerate the adoption and reimbursement of innovative health technologies through a single, harmonized, pre-market, evidence-based process.

EXCITE has selected ApneaDx Inc., Medtronic of Canada Ltd. and Rna Diagnostics Inc. as the program’s initial participants.

Five UTEST companies to tackle critical healthcare challenges

Program’s second cohort includes eQOL, E-Twenty Development, Root2Crown, Treata Smart Solutions and TrendMD

TORONTO (May 14, 2013) — Five companies tackling pervasive healthcare challenges — such as assessing dental health, helping patients and medical personnel navigate hospitals with greater ease, staying current with medical literature, or creating digital tools to help care for the elderly or those with chronic health conditions — have been admitted to the University of Toronto Early Stage Technology (UTEST) program’s second cohort.

UTEST, supported by the University of Toronto’s Connaught Fund, Innovations & Partnerships Office (IPO) and MaRS Innovation (MI), is part of a growing system of incubators and commercialization support services at U of T.

Two companies in UTEST’s second cohort, E-Twenty Development Inc. and Treata Smart Solutions Inc. are participating in Canada 3.0 at the Metro Convention Centre May 14 and 15, 2013, in Toronto.

This announcement was covered in PE Hub.

Each company will receive up to $25,000, incubation space in the MaRS Discovery District, mentoring and business strategy support to develop protectable intellectual property, launch their products and gain market traction. They are also eligible to become clients of MaRS Discovery District’s ICE or Healthcare practices.

UTEST seeks scalable, enterprise-focused software applications interested in building business-to-business customer bases — and preferably operational products with a short term to market. The program is co-directed by Kurtis Scissons (U of T IPO) and Dr. Lyssa Neel (MI).

The second cohort has big shoes to fill. UTEST’s first cohort has collectively secured over $1.2 million in follow-on funding and currently employs 29 highly skilled people (HQPs). Each company also filed solid patent protection and most have secured customers. Notably, Whirlscape’s Indiegogo campaign secured over $87,000 in crowd-sourced product funds from nearly 10,000 users, and was featured in the Financial Post, TechCrunch, Mashable and The Verge, among other global media outlets.

Canadian biotech sector makes strong showing at BIO2013

Every six weeks, MaRS Innovation’s marketing and communications manager writes a guest post for the MaRS Discovery District blog profiling MI’s activities or one of our start-up companies. You can read the original post on the MaRS blog.

Downtown Chicago skyline in late April — **Chicago**‘s famous downtown skyline during the 2013 BIO Convention.

Nearly 14,000 delegates—representing over 1,100 biotechnology companies, academic institutions, state biotechnology centres and related organizations across the United States and more than 60 countries—attended the 2013 BIO International Convention from April 22 to 26, 2013.

The event drew biotechnologists, pharmaceutical industry executives and life sciences researchers, along with sector-based organizations and associations, to Chicago.

According to a press release issued by the conference organizers, BIO 2013 offered “a record number of partnering meetings and panel sessions on the latest science, policy issues and business opportunities and challenges facing the biotechnology industry.”

How Canada’s health-care industry is riding a wave of transition

Bedside Clinical Systems featured on Research Innovation and Commercialization Centre (RICC) panel discussion In an article for YourMississaugaBiz.com, Jon Cook writes, " 'The health-care industry is relying more on the…

Stem Cell Therapeutics Merger, Technology Featured in Biotechnology Focus

MaRS Innovation focus of Yonge Street Media article on growing technology sectors

President and CEO Dr. Raphael Hofstein speaks on healthcare innovation in Toronto

WaveCheck to Transform Chemotherapy Monitoring for Women with Breast Cancer

Indiegogo campaign to raise funds for North American clinical study during Breast Cancer Awareness Month; 12 artists donate 13 original works worth over $15,000 to support campaign

Cellax profiled in SciBX; MaRS Innovation’s MSc PoP program cited in National Post supplement

Dr. Raphael Hofstein’s MRI blog post: How Team Ontario’s biotechnology takes on the world

UTEST named one of Canada’s seven true start-up accelerators

MaRS Discovery District launches MaRS EXCITE to help breakthrough technologies reach patients faster

MI start-up ApneaDx Inc. among program’s first round of participants

Five UTEST companies to tackle critical healthcare challenges

Program’s second cohort includes eQOL, E-Twenty Development, Root2Crown, Treata Smart Solutions and TrendMD

Canadian biotech sector makes strong showing at BIO2013

How Canada’s health-care industry is riding a wave of transition

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