Results for results in docetaxel-resistant prostate cancer models presented at the American Association for Cancer Research (AACR) Conference TORONTO and SAN DIEGO (April 18, 2016) — Triphase Accelerator Corporation, a private…
New research emerging from the University of Toronto’s Edward S Rogers Sr. Department of Electrical and Computer Engineering is developing and demonstrating a new class of solar-sensitive nanoparticle.
MaRS Innovation is working with Professor Ted Sargent, his research team and U of T’s Innovations and Partnerships Office (IPO) to incubate and commercialize this and other solar technologies. Their work was recently published in Nature Materials.
Here’s an excerpt from power-technology.com:
Led by post-doctoral researcher Zhijun Ning and Professor Ted Sargent, the research work resulted in the development of a new form of solid, stable light-sensitive nanoparticles, known as colloidal quantum dots.
Developed in collaboration with Dalhousie University, King Abdullah University of Science and Technology and Huazhong University of Science and Technology, the solar-sensitive nanoparticles are cheaper than the traditional panels, large and rectangular.
In addition to being cheaper, the colloidal quantum dots are more flexible solar cells, and better gas sensors, infrared lasers, infrared light emitting diodes and more.
Here’s an excerpt:
“Ontario Institute for Cancer Research scientists have developed glycopolymer-conjugated docetaxel nanoparticles that outperform Abraxane in mouse models of breast cancer. The Ontario Institute for Cancer Research (OICR) is backing the program with $1.5 million to take it to the clinic. The expectation is that the product’s ability to target the tumor stroma rather than the tumor itself will differentiate it from Abraxane and other chemotherapeutic formulations.”
Every six weeks, MaRS Innovation’s marketing and communications manager writes a guest post for the MaRS Discovery District blog profiling MI’s activities or one of our start-up companies. This post coincided with World Cancer Day.
What if you could use a cancer tumour’s proteomic profile to make it easier to target and destroy?
Targeting specific proteins on the surface of individual tumours—or, more precisely, targeting a cell receptor that naturally allows substances to pass into a cell—would allow clinicians to more effectively deliver drugs designed to deactivate cancer-promoting genes within the tumour, while minimizing the addition of toxins to the patient’s body.
Personalized medicine research in Toronto also benefited from a recent $50 million donation to support Princess Margaret Hospital (part of the University Health Network). Read and watch the news announcement on BioTechnology Focus.
This is personalized medicine’s promise for cancer treatment: targeted therapies that stand a better chance of success, with reduced side effects, based on the unique profile of a patient’s tumour, either administered on their own or in combination with traditional chemotherapy.
TORONTO, ON (November 13, 2012) — The Ontario Institute for Cancer Research (OICR) and MaRS Innovation (MI) today announced $1.5 million in funding from OICR over three years to further develop Cellax™, a nanoparticle drug that could offer an alternative to chemotherapy with fewer side effects.
“Cellax is promising because it provides a more targeted strategy for treating tumours, killing tumour cells while minimizing the effect on healthy tissue,” said Dr. Rima Al-awar, director, OICR’s Medicinal Chemistry Platform. “OICR is proud to invest in a technology that has such potential to one day improve quality of life for cancer patients.”
Cellax, invented by Dr. Shyh-Dar Li and his research team in OICR’s Medicinal Chemistry Platform group, is a drug-polymer conjugate based on Dr. Li’s proprietary NanoCMC™ technology. These polymers self-assemble into defined nanoparticles and, when injected, selectively accumulate in tumours. Because of this property, the drug is released where it is most needed, increasing therapeutic benefits and reducing the side effects associated with conventional chemotherapy.
Provincial Investment Supports Commercialization of Leading-Edge Molecular Diagnostic Screening Technology TORONTO (July 26, 2011) — Xagenic Inc., one of MaRS Innovation’s (MI) portfolio spin-off companies, was awarded $1 million in…
TORONTO (November 19, 2009) – In the drive to improve early detection and treatment of cancer, a pair of Toronto scientists has developed a unique technology that combines contrast agents with targeted, long-lasting nano-particles for use in multiple medical imaging platforms.
While contrast agents are routinely injected into patients to enhance the quality of medical images, different agents are currently required for various imaging modes (e.g. MRI, CT, PET) each with inherent strengths and limitations. By combining more than one contrast agent into a nano-particle for use in multiple types of imaging, not only are physicians and researchers able to use lower doses of contrast agents (with lower toxicity) but the nano-particle also enables targeted delivery to, and retention by, specific tumours.