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Posts Tagged: clinical studies

Triphase to present Marizomib clinical and preclinical data at American Society of Hematology’s annual meeting

TORONTO and SAN DIEGO (December 8, 2015) — Triphase Accelerator Corporation, a private drug development company dedicated to advancing novel compounds through Phase 2 proof-of-concept, today announced that positive results from its ongoing Phase 1 proof-of-concept study evaluating marizomib in patients with relapsed and refractory multiple myeloma will be presented at the 57th Annual Meeting of the American Society of Hematology (ASH). The company will also present preclinical data on marizomib demonstrating synergistic activity in combination with pomalidomide. Marizomib is a novel ... Read more

MI’s head of imaging technologies quoted on bioprinting in U.K.’s Financial Times

Fanny Sie, MaRS Innovation's head of imaging technologies, was quoted in Tanya Powley's article, "Printing whole organs remains a long way off," for the U.K.'s Financial Times on June 11, 2015, regarding the technology's potential to transform existing healthcare practices. MI does wish to note that the article inaccurately attributes the PrintAlive device's development to MaRS Innovation; MI is working with the University of Toronto inventing team, led by Dr. Axel Gunther, to commercialize the device. Here's a short excerpt: Bioprinting could save pharmaceutical ... Read more

Triphase Accelerator Corporation initiates phase I study of marizomib and bevacizumab in patients with Glioblastoma

TORONTO and SAN DIEGO, (April 22, 2015) -- Triphase Accelerator Corporation, a private drug development company dedicated to advancing novel compounds through Phase II proof-of-concept, today announced that it has initiated a Phase I proof-of-concept clinical study of marizomib. The study is evaluating an intravenous (IV) formulation of marizomib, a novel and highly potent proteasome inhibitor, in combination with bevacizumab (Avastin®) in patients with glioblastoma, the most common and aggressive malignant primary brain tumor. The study is recruiting and enrolling patients at ... Read more

MaRS Innovation’s top 10 portfolio stories for 2014

MaRS Innovation enjoyed an exceptional year in 2014. Our team continues to collaborate with researchers within our membership to help bridge the commercialization gap between their world-leading research and creating successful start-up companies or licenses. Here are our picks for the top 10 news stories from MaRS Innovation's portfolio. 1. Triphase Accelerator Corporation, in which MaRS Innovation is an investor, started the year with a bang by signing a collaboration and option agreement with Celgene Corporation. In October, Triphase initiated a Phase I clinical study ... Read more

Triphase announces proteasome inhibitor marizomib demonstrates potent synergistic anti-multiple myeloma activity in combination with pomalidomide

Findings from Preclinical Study Presented at American Society of Hematology 2014 Annual Meeting TORONTO AND SAN DIEGO (Dec. 6, 2014) -- Triphase Accelerator Corporation, a private drug development company dedicated to advancing novel compounds through Phase II proof-of-concept clinical studies, today announced preclinical study results demonstrating that the combination of its highly differentiated proteasome inhibitor, marizomib, and pomalidomide (Pomalyst®) was synergistic in killing multiple myeloma cells. MaRS Innovation is an early-stage investor in Triphase. See our web archive for more details. Combined doses of ... Read more

WaveCheck campaign part of new study on crowdfunding medical research

MI's Fazila Seker also interviewed in National Post article on what prompts medical researchers to consider crowdfunding The WaveCheck crowdfunding campaign, which raised $53,390 on Indiegogo to support clinical trials for a clinical technique invented by researchers at Sunnybrook Health Sciences Centre and Ryerson University, was included in a new Canadian-led study on the merits of crowdfunding to support cancer and rare diseases. "Crowdfunding drug development: The state of play in oncology and rare diseases," was published in Drug Discovery Today's June issue. MaRS ... Read more

WaveCheck’s Crowdfunding Campaign Featured on CTV National News and Canada AM

Indiegogo campaign raised $53,390 from over 500 worldwide donors CTV National News featured WaveCheck’s crowdfunding campaign on December 15 in a report by Avis Favaro. The report included an interview with MaRS Innovation’s President and CEO, Dr. Raphael Hofstein (at the 1:37 mark). William Tran, a researcher associated with the project at Sunnybrook Health Sciences Centre, was also interviewed on Canada AM on December 16. WaveCheck, which closed its campaign December 4, was invented by Dr. Gregory Czarnota of Sunnybrook Health Sciences Centre and ... Read more

WaveCheck raises over $41,000 for breast cancer treatment monitoring in three weeks

Over 340 people worldwide have joined WaveCheck's Indiegogo crowdfunding campaign to fund a breakthrough clinical technique for breast cancer that promises to revolutionize the way chemotherapy is monitored. "Breast Cancer Awareness Month’s positivity makes it easy to overlook the fact that 60 to 70 per cent of chemotherapy treatments fail,” says Dr. Gregory Czarnota, chief of Radiation Oncology at Sunnybrook Health Sciences Centre and co-inventor of WaveCheck with Professor Michael C. Kolios of Ryerson University. “WaveCheck’s technology can tell people with breast ... Read more