commercialization in Toronto

MaRS Innovation statement on the 2015 Federal Budget

TORONTO, ON (April 23, 2014) — MaRS Innovation congratulates the Federal Government’s deepened commitment to support Canadian research and innovation, particularly in the healthcare sector. In particular, the $42 million over five years dedicated to support the Canadian Centre for Aging and Brain Health Innovation at Baycrest Health Sciences, which includes $32 million in support from the Federal Economic Development Agency for Southern Ontario (FedDev).

Baycrest is a founding member institution of MaRS Innovation.

“As a Baycrest partner and long-time champions of the commercialization potential of its world-class science in brain and geriatric health care, MaRS Innovation welcomes this news,” says Dr. Raphael (Rafi) Hofstein, president and CEO. “We look forward to advancing existing neuroscience projects in partnership with Baycrest, such as The Virtual Brain, and to collaborating on new start-up companies and licenses related to dementia and other neurodegenerative diseases.”

Other promising budget allocations for the innovation sector include:

Triphase Accelerator announces new cancer collaboration with Sunnybrook Research Institute

February 27, 2015
Susanne Staer
Industry Partners

TORONTO and SAN DIEGO (Feb. 26, 2015) — Triphase Accelerator Corporation has entered into an academic center collaboration with Sunnybrook Research Institute (SRI), the research arm of Sunnybrook Health Sciences Centre, a MaRS Innovation member institution. MaRS Innovation is also a Triphase investor.

Under the agreement, SRI will assist in the development of Triphase’s novel, first-in-class, fully human bi-specific antibody TRPH 011 and evaluate the role of bifunctional targeting of VEGFR-2 and TIE 2 receptors in cancer. TRPH 011 binds and neutralizes VEGFR-2/KDR and TIE 2 receptors simultaneously, resulting in sustained inhibition of tumor growth and angiogenesis (the formation of new blood vessels from pre-existing vessels and a fundamental step in the transition of tumors from a benign to a malignant state).

Under the terms of the agreement, Triphase will provide funding to the laboratory of Dr. Robert S. Kerbel, senior scientist in the Biological Sciences Platform at SRI. Dr. Kerbel and his colleagues will evaluate TRPH 011 in preclinical pharmacology models. Triphase will use the findings to advance the TRPH 011 program toward an Investigational New Drug (IND) filing.

MaRS Innovation collaborating with Johnson & Johnson Innovation and Janssen to advance Cardiac, Diabetes and Depression technologies

January 12, 2015
Susanne Staer
Centre for Addiction and Mental Health (CAMH)

TORONTO, Jan. 12, 2015 — MaRS Innovation, the commercialization agent for Ontario’s 15 leading academic institutions, today announced that it has formed a research collaboration with Johnson & Johnson Innovation, LLC and its Canadian affiliate, Janssen Inc., to advance three technologies focused on cardiac, diabetes and depression, respectively.

This announcement was covered in Lab Product News.

“These three projects reflect the quality of innovation present in Toronto’s research community for our industry partners, and Toronto’s progress in addressing healthcare issues of international concern,” said Dr. Raphael Hofstein, president and CEO of MaRS Innovation. “Johnson & Johnson Innovation is a long-term strategic partner of MaRS Innovation and of our members; our collaboration reflects the benefits to accessing our members’ deal flow through MaRS Innovation. Through these deals and other scientific exchanges, we see increased interest in Toronto’s innovation and entrepreneurship community.”

The projects’ principal investigators are researchers from the University Health Network (UHN), the Centre for Addiction and Mental Health (CAMH) and the University of Toronto. This announcement follows Johnson & Johnson Innovation’s December 2013 commitment to collaborate on early-stage drug development projects.

SciBX covers Encycle’s partnership with IRICoR, MaRS Innovation and Merck

“The first disclosed grant under Merck & Co. Inc.’s Canadian translational initiative will bolster the ability of macrocycle-based Encycle Therapeutics Inc. to conduct lead optimization of its integrin [a₄b₇,] inhibitors for inflammatory bowel disease,” writes Michael J. Haas in SciBX’s feature on the partnership, “Merck Encycles through Canada.” The article appears in the publication’s December 4, 2014 issue.

Read the Encycle press release that prompted this article.

The article explores the current grant partnership between Merck, Encycle Therapeutics, MaRS Innovation, the Institute for Research in Immunology and Cancer–Commercialization of Research (IRICoR), and the Université de Montréal’s Institute for Research in Immunology and Cancer (IRIC), and takes an inside look at the company’s progress to date.

Here’s an excerpt:

Encycle is a spinout from the University of Toronto founded in 2012 to solve the primary challenges of macrocycle drugs–poor cell penetration and low oral availability.

According to Parimal Nathwani, the company was selected by MaRS Innovation and IRICoR (Institute for Research in Immunology and Cancer–Commercialization of Research), two of the three agencies originally tasked with disbursement and management of the Merck fund, because it was a good match with IRIC’s competencies. The third agency, The Centre for Drug Research and Development, is not involved in this deal. IRICoR is the commercialization arm of IRIC.

“Encycle has a good chemistry platform and nice early discovery work on its integrin [a₄b₇,] inhibitor program, which is now at the point where it needs to move through lead optimization,” said Nathwani. “IRIC scientists have strong expertise in medicinal chemistry and have worked with industry on optimization, pharmacokinetics, toxicity and other preclinical studies, so they can provide Encycle with pharma-grade optimization.”

MaRS Innovation joins new financing round for AvidBiologics Inc.

September 29, 2014
Susanne Staer
Formation Biologics

TORONTO, Sept. 29, 2014 — AvidBiologics Inc., an oncology drug development company, today announced the closing of a financing round. The company is founded on antibody-drug conjugate (ADC) technologies co-developed with the National Research Council of Canada (NRC).

Led by Lumira Capital, the financing round included MaRS Innovation (MI), MaRS Investment Accelerator Fund (IAF), Rosseau Asset Management, and the company’s founding investors.

This announcement was covered by Dow Jones: Private Equity and Venture Capital and by Canadian Private Equity.

Today’s financing builds on prior support from the Ontario Centres of Excellence (OCE), the National Research Council of Canada’s Industrial Research Assistance Program (NRC-IRAP), Ontario Ministry of Research and Innovation’s Business Accelerator Program (MRI-BAP) and other Canadian life science development organizations.

“This financing round enables us to rapidly advance our lead ADC into clinical trials,” said Ilia Tikhomirov, President and CEO. “We would like to thank the NRC and all of our partners for their support as AvidBiologics transitions from a discovery-stage to a development-stage company.”

**Dr. Raphael Hofstein**, president & CEO, MaRS Innovation.

“The high quality pre-clinical package and exceptional leadership team, including pioneers in the development of ADCs, position the company for a successful transition towards clinical development,” said Dr. Raphael Hofstein, president and CEO of MI. “The cooperation among funding organizations, such as those involved in this financing, represents the strengthening foundation on which commercialization within Toronto’s start-up community can be successfully realized. We are glad to be part of this financing syndicate that supports one of Canada’s leading life sciences companies.”

Tech Transfer Central features MaRS Innovation’s partnership with St. Michael’s Hospital

September 25, 2014
Susanne Staer
Media Coverage

Tech Transfer Tactics, the monthly newsletter for Tech Transfer Central.com, has published a feature highlighting MaRS Innovation’s Technology Transfer & Scouting (MITTS) services to St. Michael’s Hospital.

The interview explores the increase in disclosures and commercial activity achieved after MaRS Innovation began offering technology transfer services to the hospital, and was triggered by a July profile published on MaRS Innovation’s website describing the collaborative working relationship between the two organizations.

The interview includes conversations with Sahail Shariff, commercialization manager in the MITTS division, and Samar Saneinejad, director of strategic projects in the Office of the Vice President of Research at St. Michael’s, explores the success

Here’s an excerpt:

MaRS Innovation, a member institution of the Networks of Centres of Excellence of Canada, has dramatically increased invention disclosures at St. Michael’s Hospital in Toronto by providing hospital researchers with an embedded technology transfer expert who offers commercialization guidance and access to other vital tech transfer resources.

MaRS Innovation and St. Michael’s Hospital revitalizing commercialization process

For principal investigators, a key component in taking their research ideas from the bench to the market is knowing what commercialization resources exist and when to use them.

Through the MaRS Innovation’s Technology Transfer & Scouting division (MITTS), manager Sahail Shariff is connecting with principal investigators (PIs) at St. Michael’s Hospital in Toronto on the front-line to better understand and advance their research.

Of the 180 PIs at the hospital, the majority are clinician scientists who spend a portion of their time caring for patients.

In collaboration with Samar Saneinejad, project director in the Office of the Vice-President, Research at St. Michael’s, Shariff established a research commercialization committee with regular monthly meetings to stay connected to PIs and their research status. He’s also taken note of the time constraints facing clinician scientists, making a point to provide them with more one-on-one time.

MaRS Innovation’s **Sahail Shariff** walks the halls at St. Michael’s Hospital to provide better commercialization resources to its researchers.

Invention disclosures from researchers at St. Michael’s have increased by almost 50 percent since October 2013, when Shariff joined MaRS Innovation. He has played a key role in this success and has also helped the hospital to acquire five commercialization-related funding applications and assisted in 12 interactions between PIs and industry members.

“Walking the halls has been really valuable for investigators who have great ideas and have spent a lot of time on their research and inventions, but don’t have excess time to devote to finding the right way to develop it further,” says Shariff.

Dr. Rafi Hofstein in Biotechnology Focus: What will it take to regain Canada’s biotechnology leadership?

Biotechnology Focus, a compendium of the Canadian life sciences industry, has published a guest column by MaRS Innovation President & CEO, Dr. Raphael Hofstein.

The article explores the role life sciences assets, financing and talented management–the three Ms–must play in revitalizing Canada’s biotechnology sector:

At the close of the 20^th century, Canada was perceived as a key contributor to the success of the global biotech voyage.

You know what happened next: the mechanisms to fund early ventures collapsed together with the collapse of the Canadian venture capital industry Finding suitable investment for early-stage technologies became incredibly challenging. Facing a dearth of opportunity, talented management sailed for other harbors.

It’s satisfying that on the eve of the 2014 BIO Convention, some indicators suggest to me that we are witnessing a rebound. But to accelerate our pace while holding this bearing, Canada needs to address certain strategic elements.

At MaRS Innovation, we call them the three Ms: merchandize, management and money.

Globe and Mail: Strong incubators are key to driving innovation

Jeff Cates’ op-ed in the Globe and Mail‘s Small Business/Digital Innovation section on June 19, 2014 argues that incubators have a key role to play in fostering innovation, entrepreneurship and growing new industries in Ontario.

Cates states this is particularly true when incubators when they provide programs and services to help young entrepreneurs succeed.

The University of Toronto Early-Stage Technology program (UTEST), co-managed with MaRS Innovation, is one such program. UTEST is set to announce its third cohort within the next month.

MI’s Fanny Sie to speak about 3D printing trends at two Toronto events

May 8, 2014
Susanne Staer
News

Fanny-Sie-web-7227 — **Fanny Sie** is a manager in MI’s Technology & Venture Development group and head, Imaging Technologies Area.

Fanny Sie, MaRS Innovation’s head of imaging technologies and a manager in the Technology & Venture Development group, is speaking about bioprinting trends at two Toronto conferences this weekend.

Sie is MI’s commercialization lead on the Bioprinter, a licensenable technology from the University of Toronto and Sunnybrook Health Sciences Centre.

Watch her interview on bioprinting with TVO’s The Agenda, which aired in June 2013.

First up is Digifest, an international festival celebrating digital creativity, which runs from May 8 to 10 at the Corus Quay building on Toronto’s Waterfront. Sie will speak about 3D printing and its biological and commercial implications on the Mass Customization Panel Discussion, which runs from 2 to 3 pm on Friday, May 9.

On Monday, Sie joins the opening panel at the OCE Discovery Conference, which runs from May 12 to 13, 2014 at the Metro Toronto Convention Centre (South Building). She will speak during the “3D Manufacturing: Beyond the Hype” panel at 9 am on May 13.