Member Institutions

Encycle Therapeutics developing lead molecule to tackle inflammatory bowel disease

Company’s collaborative partnership with IRICoR, Université de Montréal and MaRS Innovation, funded by Merck Canada, to advance macrocycle drug

Encycle IRICoR release — Encycle Therapeutics Inc., a biotechnology start-up founded by the University of Toronto in partnership with MaRS Innovation, is developing its lead orally-bioavailable macrocycle drug to target integrin a4b7, which is involved in the inflammatory process in a number of diseases, most notably for inflammatory bowel disease.

TORONTO and MONTREAL, Nov. 10, 2014 — Encycle Therapeutics Inc., a biotechnology start-up founded by Dr. Andrei Yudin of the University of Toronto in partnership with MaRS Innovation, is developing its lead orally-bioavailable macrocycle drug to target integrin a₄b₇, which is involved in the inflammatory process in a number of diseases, most notably for inflammatory bowel disease.

This announcement was covered in SciBX, Drug Discovery & Development, PBR, Yonge Street Media, Biotechnology Focus, and Bioworld Today (no public link available).

Read this release in French.

To support and advance this molecule, Encycle Therapeutics is collaboratively partnering with the Institute for Research in Immunology and Cancer — Commercialization of Research (IRICoR), the Université de Montréal (UdeM) and MaRS Innovation. The partnership builds on the Merck Canada Inc. $4 million public-private funding partnership, announced at BIO in April 2013, to develop collaborative research projects with three Canadian academic commercialization centres, including MaRS Innovation and IRICoR.

“We are pleased to help support this important research collaboration that is made possible through the Quebec-Ontario corridor project in an emerging technology area. IRICoR, MaRS Innovation and Encycle have clearly leveraged their respective strengths to accelerate the discovery of novel therapeutics. As a research-focused company committed to early stage private-public partnering, we believe that such interactions will continue to fuel innovation in the life science sector in Canada,” said Mr. Chirfi Guindo, president and managing director, Merck Canada Inc.

The agreement brings a significant investment to fund Encycle Therapeutics’ development work, giving IRICoR an equity position and expanding MaRS Innovation’s equity stake. Cumulatively, Encycle Therapeutics has secured more than $2.5 million to advance its drug development platform.

Triphase announces Celgene collaborations and license deal with PharmAbcine

October 28, 2014
Susanne Staer
Industry Partners

Triphase Accelerator Corporation, a private, drug development company dedicated to advancing novel compounds through Phase II proof-of-concept, announced October 27, 2014 new and expanded strategic collaborations with Celgene Corporation.

This announcement was covered in Genetic Engineering and Biotechnology News (GEN), BioCentury Extra (no link available), Pharmaceutical Business Review (no link available), Scrip and BioWorld Today (no link available). It builds on Triphase’s original collaborative agreement with Celgene in January 2014.

The company has also announced a new global license for a fully human, bi-specific antibody targeting VEGFR-2/TIE 2 with Korea’s PharmAbcine.

Triphase initiates Phase I Study Evaluating Marizomib in Glioblastoma (GBM) with Celgene

Triphase has expanded its strategic collaboration with Celgene Corporation. The supplemental agreement adds a Phase I development program that will explore combining an intravenous (IV) formulation of marizomib with bevacizumab in glioblastoma (GBM), an aggressive malignant primary brain tumour.

BioCentury features Vasomune Therapeutics

October 27, 2014
Susanne Staer
Media Coverage

Vasomune Therapeutics, a MaRS Innovation start-up company from Sunnybrook Health Sciences Centre’s Sunnybrook Research Institute, was featured in a BioCentury emerging company profile by Michael J. Haas.

The company is currently raising a Series A financing round and recently closed a seed investment with Genome Canada and an unnamed industry partner. MaRS Innovation also contributed a third of the investment, bringing the round’s total to $1.5 million.

Haas’ profile, “Vasomune: Lassoing Tie2,” is available behind a paywall on the BioCentury website.

Here’s a short excerpt:

Agonizing Tie2 could restore vascular integrity and limit tissue damage in kidney injury, but bringing together the four copies needed to activate the receptor is a job too big for small molecules or antibodies. Vasomune Therapeutics Inc. has shown its four-armed peptidomimetic, vasculotide, activates Tie2 and restores vascular integrity in [preclinical] models.

“Many renal diseases are ultimately characterized by a loss in vascular integrity that damages tubules in the kidney,” CEO Parimal Nathwani said. “Our idea is to use vasculotide to fix the problem and restore normal vascular integrity before it gets out of control.”

Vasomune Therapeutics awarded $1.5 million to advance lead asset for renal disease

TORONTO (October 20, 2014) — Vasomune Therapeutics, a biotechnology start-up founded by Drs. Dan Dumont and Paul Van Slyke of Sunnybrook Research Institute (SRI) in partnership with MaRS Innovation, has received $1.5 million, in part through Genome Canada’s Genomic Applications Partnership Program (GAPP), to advance Vasculotide, the company’s lead Tie-2 activating agent, towards clinical development.

This announcement was covered in Biotechnology Focus.

The Honourable Ed Holder, Minister of State (Science and Technology) and Dr. Pierre Meulien, president and CEO of Genome Canada, announced the funding as part of 12 selected projects under Genome Canada’s Genomic Applications Partnership Program (GAPP), on October 15 in Wallenstein, Ontario.

**Parimal Nathwani**, president and CEO of Vasomune Therapeutics Inc.

“We believe that our technology is well positioned to accelerate from preclinical research into clinical development based on its strong data package,” said Parimal Nathwani, president and CEO of Vasomune Therapeutics. “This award, in combination with industry funding, validates the Vasculotide opportunity and gives us the required funds to advance the drug candidate toward the clinic.”

In preclinical studies, Vasculotide has shown to be an effective treatment for multiple renal diseases including acute kidney injury (AKI), which in humans is a possible outcome of kidney function loss that manifests in nearly a third of high-risk cardiac patients. AKI may result from short-term interruptions in blood flow during surgery; 11 percent of patients who develop AKI after bypass surgery will die. People who survive AKI are at risk of developing longer-term kidney complications such as chronic kidney disease or End Stage Renal Disease. Vasomune’s founders conceptualized and designed Vasculotide to bind to the Tie-2 receptor, which is responsible for maintaining vascular health (and thus blood flow).

With this new funding, a third from Vasomune and MaRS Innovation, a third from Genome Canada and a third from a leading multinational pharmaceutical company, Vasomune can transition its program into manufacturing optimization, pharmacokinetics and toxicology studies to prepare for clinical development in early 2016.

Xagenic announces $6 million GAAP partnership for Hepatitis C testing; appoints president and CEO

Xagenic Inc., a molecular diagnostics company developing the first lab-free molecular diagnostic platform with a 20 minute time-to-result, announced October 15, 2014 that its project in partnership with the University of Toronto was successful in securing funding from Genome Canada under the Genomic Applications Partnership Program (GAPP).

The funding, announced by the Honourable Ed Holder, Minister of State (Science and Technology) and Dr. Pierre Meulien, president and CEO of Genome Canada, is part of 12 selected projects under Genome Canada’s Genomic Applications Partnership Program (GAPP), on October 15 in Wallenstein, Ontario.

The project titled “Development of Low Cost Testing Chip and Device for Hepatitis C Testing” was approved with funding up to a maximum of $5,999,865 over three years. The Ontario Ministry of Research and Innovation is supporting the project with a grant matching the Genome Canada contribution.

“This is a tremendous opportunity for us to leverage the viral assay development and electrochemical detection expertise in the labs of Dr. Shana Kelley and Dr. Edward Sargent at the University of Toronto to significantly advance our own research programs on several fronts,” said Dr. Graham D. Jack, Xagenic’s senior director of Research and Development. “Under this joint program, we anticipate development of a new lower-cost substrate chip, which will significantly bring down the total cost of our in-cartridge AuRA™ detection technology.

Timothy I. Still appointed Xagenic’s president and CEO

On October 16, 2014, Xagenic also announced that Timothy I. Still has been appointed president and CEO, and will serve as a member of Xagenic Inc.’s board of directors.

This announcement was covered in PE Hub.

Toronto Star features Minuum keyboard’s successful iPhone product launch

October 7, 2014
Susanne Staer
Media Coverage

Whirlscape founders William Walmsley (left), Severin Smith and Xavier Snelgrove. The company is a graduate of the UTEST program's first cohort. — Whirlscape founders Will Walmsley (left), Severin Smith and Xavier Snelgrove. The company is a graduate of the UTEST program’s first cohort.

UTEST graduate Whirlscape was featured in Raju Mudhar’s Toronto Star article, “Toronto’s Whirlscape debuts tiny Minuum keyboard on iPhone,” which examines the company’s successful launch of their innovative, one-line keyboard for Apple’s iOS 8.

The UTEST program, co-directed by MaRS Innovation and the University of Toronto’s Innovations & Partnerships Office, gives nascent software companies start-up funding, office space, mentoring and business strategy support. Whirlscape was among the program’s first cohort.

The article was published October 6, 2014. Here’s an excerpt:

An Indiegogo success 18 months ago, the company created a tiny keyboard called Minuum for Android devices. Now, iOS and the vast Apple market beckoned. It required new hires, a couple months of round-the-clock development, and a practical rebuilding of their product from scratch so it could be ready to launch with iOS 8. All the work paid off: in the first two weeks of availability, they have sold more than 30,000 apps to the new iPhone audience.

Kaypok, MI’s director of intellectual property quoted in the Financial Post

September 26, 2014
Susanne Staer
Kaypok Inc.

Article focuses on importance of intellectual property protection for small businesses

StacyIvanchuck8791 — **Dr. Stacey Ivanchuk**, director of intellectual property for MaRS Innovation.

Dr. Stacey Ivanchuk, MaRS Innovation’s director of intellectual property, was quoted in Denise Deveau’s article, “Intellectual property protection is a game small businesses can’t afford to lose,” for the Financial Post on September 26, 2014 regarding the importance of protecting intellectual property for small businesses.

Here’s an excerpt:

Stacey Ivanchuk, director of intellectual property for MaRS Innovation in Toronto, says that protecting a startup’s technology is important especially from an investor’s perspective.

“One of the first questions investors will ask a company is, what is your IP position? To them it’s something they can talk about as an asset and shows that you are distinguishing yourself,” [Dr.] Ivanchuk said.

Ivanchuk said businesses run the gamut from doing nothing to protect their ideas to filing for patents on every idea that comes out of a brainstorming session. “Too early is not good because it can be a waste of money if the proof you expected down the road doesn’t happen,” she said. “But if you wait too long someone might beat you to the punch.”

The article also quotes Atul Asthana, CEO of Kaypok, a tech start-up in the text analytics space spun out from York University in partnership with MaRS Innovation:

In the high tech world especially, it’s not always easy to determine whether something should be protected or not, according to Mr. Asthana. “You have to be able to enforce it. If you do it poorly, you will be giving your ideas away and spending a whole bunch of money. It can become a real cat and mouse game sometimes,” he said.

Tech Transfer Central features MaRS Innovation’s partnership with St. Michael’s Hospital

September 25, 2014
Susanne Staer
Media Coverage

Tech Transfer Tactics, the monthly newsletter for Tech Transfer Central.com, has published a feature highlighting MaRS Innovation’s Technology Transfer & Scouting (MITTS) services to St. Michael’s Hospital.

The interview explores the increase in disclosures and commercial activity achieved after MaRS Innovation began offering technology transfer services to the hospital, and was triggered by a July profile published on MaRS Innovation’s website describing the collaborative working relationship between the two organizations.

The interview includes conversations with Sahail Shariff, commercialization manager in the MITTS division, and Samar Saneinejad, director of strategic projects in the Office of the Vice President of Research at St. Michael’s, explores the success

Here’s an excerpt:

MaRS Innovation, a member institution of the Networks of Centres of Excellence of Canada, has dramatically increased invention disclosures at St. Michael’s Hospital in Toronto by providing hospital researchers with an embedded technology transfer expert who offers commercialization guidance and access to other vital tech transfer resources.

BioDiaspora founder appears on CBC’s “The National” to discuss the Ebola crisis

September 24, 2014
Susanne Staer
Media Coverage

Dr. Kamran Khan, founder of BioDiaspora, appeared on CBC’s “The National” on September 23, 2014, as part of a health panel examining the current state of the Ebola outbreak in west Africa.

CBC anchor Peter Mansbridge hosted the discussion.

Dr. Kamran Khan, an infectious disease clinician-scientist at St. Michael's Hospital and founder of BioDiaspora, on CBC's "The National." — Dr. Kamran Khan, an infectious disease clinician at St. Michael’s Hospital and founder of BioDiaspora, on CBC’s “The National.”

Watch the clip on CBC’s website.

BioDiaspora, spun off from St. Michael’s Hospital in partnership with MaRS Innovation, developed an easy-to-access, web-based solution that generates and communicates customized, actionable intelligence about global infectious disease threats in real-time.

University of Toronto’s entrepreneurship programs to share over $3 million from province’s Campus-Linked Accelerator Program

UTEST among the four U of T entrepreneurship programs to be funded through Ontario’s CLA program

The University of Toronto will receive $3,056,000 in funding over two years from the Ontario government to increase its training and support for student entrepreneurship.

The funding is part of the Campus-Linked Accelerator Program (CLA), announced today by Reza Moridi, Ontario’s Minister of Research and Innovation, and Minister of Training, Colleges and Universities.

“Fostering the entrepreneurial spirit among students is a key component of Ontario’s Youth Jobs Strategy, through programs that help transfer their ideas and skills to the marketplace while creating rewarding careers,” said Minister Moridi. “By partnering with colleges and universities to support entrepreneurship, we are ensuring our province’s business leaders of tomorrow are getting the support they need to succeed today.”

With this funding, U of T will continue to build on its long track record of success in this area by expanding the entrepreneurship opportunities it offers to students, primarily through its four principal accelerators: The Creative Destruction Lab (Rotman School of Management), The Hatchery (Faculty of Applied Science and Engineering), The Impact Centre (Faculty of Arts & Science), and UTEST (The Innovation and Partnerships Office, produced in partnership with MaRS Innovation).

The CLA program provides critical funding that enhances the support U of T and MaRS Innovation offer to our current UTEST companies,” said Kurtis Scissons, co-director of UTEST. “It also allows UTEST to expand to work with a greater number of student entrepreneurs in computer software, and is a catalyst for other UT CLA’s to combine their entrepreneurship efforts in a synergistic, complimentary way.”