Encycle is exploiting a unique platform technology that enables rapid synthesis of small, drug-like macrocycles.
Encycle’s scientific founder, Dr. Andrei Yudin, pioneered a technique to synthesize macrocycles using amphoteric reagents called aziridine aldehydes. Aziridine aldehyde-based macrocycles, or nacellins, possess several advantages over macrocycles synthesized using traditional chemistry, such as a significantly enhanced ability to passively diffuse across cell membranes. This attribute opens up new therapeutic avenues, including the potential to generate orally bioavailable modulators of protein-protein interactions, as well as potent modulators of intracellular protein-protein interactions.